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Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer
Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate ligand-independent signaling are common in non–small cell lung cancer (NSCLC), including kinase domain mutations L858R (also calle...
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| Pubblicato in: | Mol Biol Cell |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Cell Biology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4710239/ https://ncbi.nlm.nih.gov/pubmed/26337388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0269 |
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