Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate ligand-independent signaling are common in non–small cell lung cancer (NSCLC), including kinase domain mutations L858R (also calle...

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Publié dans:Mol Biol Cell
Auteurs principaux: Valley, Christopher C., Arndt-Jovin, Donna J., Karedla, Narain, Steinkamp, Mara P., Chizhik, Alexey I., Hlavacek, William S., Wilson, Bridget S., Lidke, Keith A., Lidke, Diane S.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710239/
https://ncbi.nlm.nih.gov/pubmed/26337388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0269
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