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ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding
The extent to which ligand occupancy and dimerization contribute to erbB1 signaling is controversial. To examine this, we utilized two-color Quantum Dot tracking for visualization of erbB1 homodimerization and quantification of the dimer off rate (k(off)) on living cells. Kinetic parameters were ext...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210321/ https://ncbi.nlm.nih.gov/pubmed/22020299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2135 |
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