Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Accumulating evidence indicates that microglial TLR2 and TLR4 play a significant role in nociception. Experiments were conducted to evaluate the contribution of TLR2 and TLR4 and their adaptor molecules to neuropathy and their ability to amplify opioid effectiveness. Behavioral tests (von Frey'...

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Detalhes bibliográficos
Publicado no:Neural Plast
Main Authors: Jurga, Agnieszka M., Rojewska, Ewelina, Piotrowska, Anna, Makuch, Wioletta, Pilat, Dominika, Przewlocka, Barbara, Mika, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709736/
https://ncbi.nlm.nih.gov/pubmed/26962463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5238730
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