Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Accumulating evidence indicates that microglial TLR2 and TLR4 play a significant role in nociception. Experiments were conducted to evaluate the contribution of TLR2 and TLR4 and their adaptor molecules to neuropathy and their ability to amplify opioid effectiveness. Behavioral tests (von Frey'...

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Publicado en:Neural Plast
Main Authors: Jurga, Agnieszka M., Rojewska, Ewelina, Piotrowska, Anna, Makuch, Wioletta, Pilat, Dominika, Przewlocka, Barbara, Mika, Joanna
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709736/
https://ncbi.nlm.nih.gov/pubmed/26962463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5238730
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