Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Accumulating evidence indicates that microglial TLR2 and TLR4 play a significant role in nociception. Experiments were conducted to evaluate the contribution of TLR2 and TLR4 and their adaptor molecules to neuropathy and their ability to amplify opioid effectiveness. Behavioral tests (von Frey'...

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Bibliografski detalji
Izdano u:Neural Plast
Glavni autori: Jurga, Agnieszka M., Rojewska, Ewelina, Piotrowska, Anna, Makuch, Wioletta, Pilat, Dominika, Przewlocka, Barbara, Mika, Joanna
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709736/
https://ncbi.nlm.nih.gov/pubmed/26962463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5238730
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