Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

Accumulating evidence indicates that microglial TLR2 and TLR4 play a significant role in nociception. Experiments were conducted to evaluate the contribution of TLR2 and TLR4 and their adaptor molecules to neuropathy and their ability to amplify opioid effectiveness. Behavioral tests (von Frey'...

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Dettagli Bibliografici
Pubblicato in:Neural Plast
Autori principali: Jurga, Agnieszka M., Rojewska, Ewelina, Piotrowska, Anna, Makuch, Wioletta, Pilat, Dominika, Przewlocka, Barbara, Mika, Joanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709736/
https://ncbi.nlm.nih.gov/pubmed/26962463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5238730
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