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Molecular mechanism of peptide editing in the tapasin–MHC I complex

Immune recognition of infected or malignantly transformed cells relies on antigenic peptides exposed at the cell surface by major histocompatibility complex class I (MHC I) molecules. Selection and loading of peptides onto MHC I is orchestrated by the peptide-loading complex (PLC), a multiprotein as...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fisette, Olivier, Wingbermühle, Sebastian, Tampé, Robert, Schäfer, Lars V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709564/
https://ncbi.nlm.nih.gov/pubmed/26754481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19085
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