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Partial Dissociation of Truncated Peptides Influences the Structural Dynamics of the MHCI Binding Groove
Antigen processing on MHCI involves the exchange of low-affinity peptides by high-affinity, immunodominant ones. This peptide editing process is mediated by tapasin and ERAAP at the peptide C- and N-terminus, respectively. Since tapasin does not contact the peptide directly, a sensing mechanism invo...
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| Publicado no: | Front Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5394104/ https://ncbi.nlm.nih.gov/pubmed/28458665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00408 |
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