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Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch

Salt bridges in lipid bilayers play a decisive role in the dynamic assembly and downstream signaling of the natural killer and T-cell receptors. Here, we describe the identification of an inter-subunit salt bridge in the membrane within yet another key component of the immune system, the peptide-loa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Blees, Andreas, Reichel, Katrin, Trowitzsch, Simon, Fisette, Olivier, Bock, Christoph, Abele, Rupert, Hummer, Gerhard, Schäfer, Lars V., Tampé, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661472/
https://ncbi.nlm.nih.gov/pubmed/26611325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17341
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