Metabolism of (13)C(5)-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase

Excessive endogenous oxalate synthesis can result in calcium oxalate kidney stone formation and renal failure. Hydroxyproline catabolism in the liver and kidney contributes to endogenous oxalate production in mammals. To quantify this contribution we have infused Wt mice, Agxt KO mice deficient in l...

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Bibliografiske detaljer
Udgivet i:Biochim Biophys Acta
Main Authors: Li, Xingsheng, Knight, John, Fargue, Sonia, Buchalski, Brianna, Guan, Zhengrong, Inscho, Edward W, Liebow, Abigail, Fitzgerald, Kevin, Querbes, William, Lowther, W. Todd, Holmes, Ross P.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706777/
https://ncbi.nlm.nih.gov/pubmed/26655602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.12.001
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