The Effects of the Inactivation of Hydroxyproline Dehydrogenase on Urinary Oxalate and Glycolate Excretion in Mouse Models of Primary Hyperoxaluria

The major clinical manifestation of the Primary Hyperoxalurias (PH) is increased production of oxalate, as a consequence of genetic mutations that lead to aberrant glyoxylate and hydroxyproline metabolism. Hyperoxaluria can lead to the formation of calcium-oxalate kidney stones, nephrocalcinosis and...

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Bibliografiset tiedot
Julkaisussa:Biochim Biophys Acta Mol Basis Dis
Päätekijät: Buchalski, Brianna, Wood, Kyle D, Challa, Anil, Fargue, Sonia, Holmes, Ross P, Lowther, W Todd, Knight, John
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047938/
https://ncbi.nlm.nih.gov/pubmed/31821850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.165633
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