An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria

Primary hyperoxaluria type 1 (PH1), an inherited rare disease of glyoxylate metabolism, arises from mutations in the enzyme alanine-glyoxylate aminotransferase. The resulting deficiency in this enzyme leads to abnormally high oxalate production resulting in calcium oxalate crystal formation and depo...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Liebow, Abigail, Li, Xingsheng, Racie, Timothy, Hettinger, Julia, Bettencourt, Brian R., Najafian, Nader, Haslett, Patrick, Fitzgerald, Kevin, Holmes, Ross P., Erbe, David, Querbes, William, Knight, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5280024/
https://ncbi.nlm.nih.gov/pubmed/27432743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016030338
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