A Higher Activation Threshold of Memory CD8(+) T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8(+) T cell response to the immunodominant Mtb antigen TB...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Carpenter, Stephen M., Nunes-Alves, Cláudio, Booty, Matthew G., Way, Sing Sing, Behar, Samuel M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706326/
https://ncbi.nlm.nih.gov/pubmed/26745507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005380
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg