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A Higher Activation Threshold of Memory CD8(+) T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis
T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8(+) T cell response to the immunodominant Mtb antigen TB...
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Publicado no: | PLoS Pathog |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4706326/ https://ncbi.nlm.nih.gov/pubmed/26745507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005380 |
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