Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with an overall survival rate of less than 5%. The poor patient outcome in PDAC is largely due to the high prevalence of systemic metastasis at the time of diagnosis and lack of effective therapeutics that target disseminated ce...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Fujimura, Ken, Choi, Sunkyu, Wyse, Meghan, Strnadel, Jan, Wright, Tracy, Klemke, Richard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706006/
https://ncbi.nlm.nih.gov/pubmed/26483550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687418
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