A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer

Deregulation of protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression. eIF5A1, and its highly related isoform eIF5A2, are translation initiation factors that have been implicated in a range of human malignancies, but how they control cancer development an...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Fujimura, Ken, Wright, Tracy, Strnadel, Jan, Kaushal, Sharmeela, Metildi, Cristina, Lowy, Andrew M., Bouvet, Michael, Kelber, Jonathan A., Klemke, Richard L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233190/
https://ncbi.nlm.nih.gov/pubmed/25261239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1031
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