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In Vivo Serial Selection of Human Pancreatic Cancer in Orthotopic Mouse Models Produces High Metastatic Variants Irrespective of Kras Status

INTRODUCTION: Kras mutations have been thought to play an important role in pancreatic cancer progression. In this study, we evaluated how serially passaging primary pancreatic tumors with and without Kras mutations, in nude mice, can generate more aggressive variants of human pancreatic cancer. MAT...

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書誌詳細
主要な著者: Metildi, Cristina A., Kaushal, Sharmeela, Hoffman, Robert M., Bouvet, Michael
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724759/
https://ncbi.nlm.nih.gov/pubmed/23590868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.03.049
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