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Ratiometric Activatable Cell-Penetrating Peptides Label Pancreatic Cancer, Enabling Fluorescence-Guided Surgery, Which Reduces Metastases and Recurrence in Orthotopic Mouse Models

BACKGROUND: The aim of this study was to evaluate the efficacy of using matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9)-cleavable ratiometric activatable cell-penetrating peptides (RACPPs) conjugated to Cy5 and Cy7 fluorophores to accurately label pancreatic cancer for fluo...

Полное описание

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Библиографические подробности
Опубликовано в: :Ann Surg Oncol
Главные авторы: Metildi, Cristina A., Felsen, Csilla N., Savariar, Elamprakash N., Nguyen, Quyen T., Kaushal, Sharmeela, Hoffman, Robert M., Tsien, Roger Y., Bouvet, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400250/
https://ncbi.nlm.nih.gov/pubmed/25319581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-014-4144-1
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