KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer

Early biomarkers and effective therapeutic strategies are desperately needed to treat pancreatic ductal adenocarcinoma (PDAC), which has a dismal 5-year patient survival rate. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancrea...

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Autori principali: Kelber, Jonathan A., Reno, Theresa, Kaushal, Sharmeela, Metildi, Cristina, Wright, Tracy, Stoletov, Konstantin, Weems, Jessica M., Park, Frederick D., Mose, Evangeline, Wang, Yingchun, Hoffman, Robert M., Lowy, Andrew M., Bouvet, Michael, Klemke, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366503/
https://ncbi.nlm.nih.gov/pubmed/22589274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3552
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