KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer

Early biomarkers and effective therapeutic strategies are desperately needed to treat pancreatic ductal adenocarcinoma (PDAC), which has a dismal 5-year patient survival rate. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancrea...

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Detalhes bibliográficos
Main Authors: Kelber, Jonathan A., Reno, Theresa, Kaushal, Sharmeela, Metildi, Cristina, Wright, Tracy, Stoletov, Konstantin, Weems, Jessica M., Park, Frederick D., Mose, Evangeline, Wang, Yingchun, Hoffman, Robert M., Lowy, Andrew M., Bouvet, Michael, Klemke, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366503/
https://ncbi.nlm.nih.gov/pubmed/22589274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3552
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