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Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6′-GNTI was proved to be a G-protein biased agonist, whereas 5′-GNTI acts as an antagonist. To investigate the molecular mechanism of...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4705513/ https://ncbi.nlm.nih.gov/pubmed/26742690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18913 |
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