Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

BACKGROUND: Nor-BNI, GNTI and JDTic induce selective κ opioid antagonism that is delayed and extremely prolonged, but some other effects are of rapid onset and brief duration. The transient effects of these compounds differ, suggesting that some of them may be mediated by other targets. RESULTS: In...

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Bibliographic Details
Main Authors: Munro, Thomas A., Huang, Xi-Ping, Inglese, Carmela, Perrone, Maria Grazia, Van't Veer, Ashlee, Carroll, F. Ivy, Béguin, Cécile, Carlezon, William A., Colabufo, Nicola A., Cohen, Bruce M., Roth, Bryan L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747596/
https://ncbi.nlm.nih.gov/pubmed/23976952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070701
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