Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

BACKGROUND: Nor-BNI, GNTI and JDTic induce selective κ opioid antagonism that is delayed and extremely prolonged, but some other effects are of rapid onset and brief duration. The transient effects of these compounds differ, suggesting that some of them may be mediated by other targets. RESULTS: In...

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Autors principals: Munro, Thomas A., Huang, Xi-Ping, Inglese, Carmela, Perrone, Maria Grazia, Van't Veer, Ashlee, Carroll, F. Ivy, Béguin, Cécile, Carlezon, William A., Colabufo, Nicola A., Cohen, Bruce M., Roth, Bryan L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747596/
https://ncbi.nlm.nih.gov/pubmed/23976952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070701
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