Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

BACKGROUND: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell membranes, thus slowing elimination and prolonging th...

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Hlavní autoři: Munro, Thomas A, Berry, Loren M, Van’t Veer, Ashlee, Béguin, Cécile, Carroll, F Ivy, Zhao, Zhiyang, Carlezon, William A, Cohen, Bruce M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411462/
https://ncbi.nlm.nih.gov/pubmed/22642416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-12-5
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