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Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI

The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6′-GNTI was proved to be a G-protein biased agonist, whereas 5′-GNTI acts as an antagonist. To investigate the molecular mechanism of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cheng, Jianxin, Sun, Xianqiang, Li, Weihua, Liu, Guixia, Tu, Yaoquan, Tang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705513/
https://ncbi.nlm.nih.gov/pubmed/26742690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18913
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