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Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1
The corticotropin releasing factors receptor-1 and receptor-2 (CRF(1)R and CRF(2)R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF(1)R have been developed for the potential treatment of anxiety disorders and alcohol addiction. It has been found that antagonists...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4308710/ https://ncbi.nlm.nih.gov/pubmed/25628267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08066 |
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