Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins)

CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties of astressin B analogues {cyclo(30–33)[D-Phe(12),Nle(21,38),C(α)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h/r-CRF((9–41))}. Out of 37 novel pepti...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Erchegyi, Judit, Wang, Lixin, Gulyas, Jozsef, Samant, Manoj, Perrin, Marilyn H., Lewis, Kathy, Miller, Charleen, Vaughan, Joan, Donaldson, Cynthia, Fischer, Wolfgang, Low, William, Yakabi, Seiichi, Karasawa, Hiroshi, Taché, Yvette, Rivier, Catherine, Rivier, Jean
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959268/
https://ncbi.nlm.nih.gov/pubmed/26789203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00926
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