Residues of Corticotropin Releasing Factor-binding Protein (CRF-BP) That Selectively Abrogate Binding to CRF but Not to Urocortin 1

Corticotropin releasing factor-binding protein (CRF-BP) binds CRF and urocortin 1 (Ucn 1) with high affinity, thus preventing CRF receptor (CRFR) activation. Despite recent progress on the molecular details that govern interactions between CRF family neuropeptides and their cognate receptors, little...

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Autori principali: Huising, Mark O., Vaughan, Joan M., Shah, Shaili H., Grillot, Katherine L., Donaldson, Cynthia J., Rivier, Jean, Flik, Gert, Vale, Wylie W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276373/
https://ncbi.nlm.nih.gov/pubmed/18234674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709904200
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