Amyloid Assemblies of Influenza A Virus PB1-F2 Protein Damage Membrane and Induce Cytotoxicity

PB1-F2 is a small accessory protein encoded by an alternative open reading frame in PB1 segments of most influenza A virus. PB1-F2 is involved in virulence by inducing mitochondria-mediated immune cells apoptosis, increasing inflammation, and enhancing predisposition to secondary bacterial infection...

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Foilsithe in:J Biol Chem
Main Authors: Vidic, Jasmina, Richard, Charles-Adrien, Péchoux, Christine, Da Costa, Bruno, Bertho, Nicolas, Mazerat, Sandra, Delmas, Bernard, Chevalier, Christophe
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Molecular Biophysics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705394/
https://ncbi.nlm.nih.gov/pubmed/26601953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652917
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