Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency exhibits considerable allelic heterogeneity which manifests with variable biochemical and clinical penetrance. It has long been thought that G6PD deficiency confers partial protection against severe malaria, however prior genetic associ...

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Bibliografiska uppgifter
I publikationen:Malar J
Huvudupphovsmän: Shah, Shivang S., Rockett, Kirk A., Jallow, Muminatou, Sisay-Joof, Fatou, Bojang, Kalifa A., Pinder, Margaret, Jeffreys, Anna, Craik, Rachel, Hubbart, Christina, Wellems, Thomas E., Kwiatkowski, Dominic P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704392/
https://ncbi.nlm.nih.gov/pubmed/26738565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-1045-0
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