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Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction

Rifampin is a key sterilizing drug in the treatment of tuberculosis (TB). It induces its own metabolism, but neither the onset nor the extent of autoinduction has been adequately described. Currently, the World Health Organization recommends a rifampin dose of 8 to 12 mg/kg of body weight, which is...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Chirehwa, Maxwell T., Rustomjee, Roxana, Mthiyane, Thuli, Onyebujoh, Philip, Smith, Peter, McIlleron, Helen, Denti, Paolo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704145/
https://ncbi.nlm.nih.gov/pubmed/26552972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01830-15
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