A Semimechanistic Pharmacokinetic-Enzyme Turnover Model for Rifampin Autoinduction in Adult Tuberculosis Patients

The currently recommended doses of rifampin are believed to be at the lower end of the dose-response curve. Rifampin induces its own metabolism, although the effect of dose on the extent of autoinduction is not known. This study aimed to investigate rifampin autoinduction using a semimechanistic pha...

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Detalhes bibliográficos
Main Authors: Smythe, Wynand, Khandelwal, Akash, Merle, Corinne, Rustomjee, Roxana, Gninafon, Martin, Bocar Lo, Mame, Sow, Oumou Bah, Olliaro, Piero L., Lienhardt, Christian, Horton, John, Smith, Peter, McIlleron, Helen, Simonsson, Ulrika S. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318330/
https://ncbi.nlm.nih.gov/pubmed/22252827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05792-11
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