Evaluation of Initial and Steady-State Gatifloxacin Pharmacokinetics and Dose in Pulmonary Tuberculosis Patients by Using Monte Carlo Simulations

A 4-month regimen of gatifloxacin with rifampin, isoniazid, and pyrazinamide is being evaluated for the treatment of tuberculosis in a phase 3 randomized controlled trial (OFLOTUB). A prior single-dose study found that gatifloxacin exposure increased by 14% in the combination. The aims of the study...

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Detalhes bibliográficos
Main Authors: Smythe, Wynand, Merle, Corinne S., Rustomjee, Roxana, Gninafon, Martin, Lo, Mame Bocar, Bah-Sow, Oumou, Olliaro, Piero L., Lienhardt, Christian, Horton, John, Smith, Peter, McIlleron, Helen, Simonsson, Ulrika S. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754315/
https://ncbi.nlm.nih.gov/pubmed/23774436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00479-13
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