A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project

BACKGROUND: There have been no major advances in tuberculosis (TB) drug development since the first East African/British Medical Research Council short course chemotherapy trial 35 years ago. Since then, the landscape for conducting TB clinical trials has profoundly changed with the emergence of HIV...

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Dades bibliogràfiques
Autors principals: Merle, Corinne SC, Sismanidis, Charalambos, Sow, Oumou Bah, Gninafon, Martin, Horton, John, Lapujade, Olivier, Lo, Mame Bocar, Mitchinson, Denis A, Perronne, Christian, Portaels, Francoise, Odhiambo, Joseph, Olliaro, Piero, Rustomjee, Roxana, Lienhardt, Christian, Fielding, Katherine
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Methodology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528451/
https://ncbi.nlm.nih.gov/pubmed/22607233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-13-61
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