A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project

BACKGROUND: There have been no major advances in tuberculosis (TB) drug development since the first East African/British Medical Research Council short course chemotherapy trial 35 years ago. Since then, the landscape for conducting TB clinical trials has profoundly changed with the emergence of HIV...

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Detalhes bibliográficos
Main Authors: Merle, Corinne SC, Sismanidis, Charalambos, Sow, Oumou Bah, Gninafon, Martin, Horton, John, Lapujade, Olivier, Lo, Mame Bocar, Mitchinson, Denis A, Perronne, Christian, Portaels, Francoise, Odhiambo, Joseph, Olliaro, Piero, Rustomjee, Roxana, Lienhardt, Christian, Fielding, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528451/
https://ncbi.nlm.nih.gov/pubmed/22607233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-13-61
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