A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project

BACKGROUND: There have been no major advances in tuberculosis (TB) drug development since the first East African/British Medical Research Council short course chemotherapy trial 35 years ago. Since then, the landscape for conducting TB clinical trials has profoundly changed with the emergence of HIV...

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Główni autorzy: Merle, Corinne SC, Sismanidis, Charalambos, Sow, Oumou Bah, Gninafon, Martin, Horton, John, Lapujade, Olivier, Lo, Mame Bocar, Mitchinson, Denis A, Perronne, Christian, Portaels, Francoise, Odhiambo, Joseph, Olliaro, Piero, Rustomjee, Roxana, Lienhardt, Christian, Fielding, Katherine
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2012
Hasła przedmiotowe:
Methodology
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528451/
https://ncbi.nlm.nih.gov/pubmed/22607233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-13-61
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