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Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction

Rifampin is a key sterilizing drug in the treatment of tuberculosis (TB). It induces its own metabolism, but neither the onset nor the extent of autoinduction has been adequately described. Currently, the World Health Organization recommends a rifampin dose of 8 to 12 mg/kg of body weight, which is...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Chirehwa, Maxwell T., Rustomjee, Roxana, Mthiyane, Thuli, Onyebujoh, Philip, Smith, Peter, McIlleron, Helen, Denti, Paolo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704145/
https://ncbi.nlm.nih.gov/pubmed/26552972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01830-15
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