Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction

Rifampin is a key sterilizing drug in the treatment of tuberculosis (TB). It induces its own metabolism, but neither the onset nor the extent of autoinduction has been adequately described. Currently, the World Health Organization recommends a rifampin dose of 8 to 12 mg/kg of body weight, which is...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Chirehwa, Maxwell T., Rustomjee, Roxana, Mthiyane, Thuli, Onyebujoh, Philip, Smith, Peter, McIlleron, Helen, Denti, Paolo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704145/
https://ncbi.nlm.nih.gov/pubmed/26552972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01830-15
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