Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction

Rifampin is a key sterilizing drug in the treatment of tuberculosis (TB). It induces its own metabolism, but neither the onset nor the extent of autoinduction has been adequately described. Currently, the World Health Organization recommends a rifampin dose of 8 to 12 mg/kg of body weight, which is...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chirehwa, Maxwell T., Rustomjee, Roxana, Mthiyane, Thuli, Onyebujoh, Philip, Smith, Peter, McIlleron, Helen, Denti, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704145/
https://ncbi.nlm.nih.gov/pubmed/26552972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01830-15
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