Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization

Bacterial type I signal peptidases (SPases) are membrane-anchored serine proteases that process the signal peptides of proteins exported via the Sec and Tat secretion systems. Despite their crucial importance for bacterial virulence and their attractiveness as drug targets, only one such enzyme, Lep...

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Bibliographic Details
Published in:IUCrJ
Main Authors: Ting, Yi Tian, Harris, Paul W. R., Batot, Gaelle, Brimble, Margaret A., Baker, Edward N., Young, Paul G.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2016
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704075/
https://ncbi.nlm.nih.gov/pubmed/26870377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252515019971
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