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Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus

Staphylococcus aureus infections are becoming increasingly difficult to treat as they rapidly develop resistance to existing antibiotics. Bacterial type I signal peptidases are membrane-associated, cell-surface serine proteases with a unique catalytic mechanism that differs from that of eukaryotic e...

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Publicat a:Acta Crystallogr F Struct Biol Commun
Autors principals: Ting, Yi Tian, Batot, Gaëlle, Baker, Edward N., Young, Paul G.
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304750/
https://ncbi.nlm.nih.gov/pubmed/25615971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X1402603X
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