Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau oligomer formation precedes the a...

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Vydáno v:Nat Commun
Hlavní autoři: Soeda, Yoshiyuki, Yoshikawa, Misato, Almeida, Osborne F. X., Sumioka, Akio, Maeda, Sumihiro, Osada, Hiroyuki, Kondoh, Yasumitsu, Saito, Akiko, Miyasaka, Tomohiro, Kimura, Tetsuya, Suzuki, Masaaki, Koyama, Hiroko, Yoshiike, Yuji, Sugimoto, Hachiro, Ihara, Yasuo, Takashima, Akihiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703892/
https://ncbi.nlm.nih.gov/pubmed/26671725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10216
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