Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau oligomer formation precedes the a...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Soeda, Yoshiyuki, Yoshikawa, Misato, Almeida, Osborne F. X., Sumioka, Akio, Maeda, Sumihiro, Osada, Hiroyuki, Kondoh, Yasumitsu, Saito, Akiko, Miyasaka, Tomohiro, Kimura, Tetsuya, Suzuki, Masaaki, Koyama, Hiroko, Yoshiike, Yuji, Sugimoto, Hachiro, Ihara, Yasuo, Takashima, Akihiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703892/
https://ncbi.nlm.nih.gov/pubmed/26671725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10216
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