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Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups
Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau oligomer formation precedes the a...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703892/ https://ncbi.nlm.nih.gov/pubmed/26671725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10216 |
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