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Modification of Tau by 8-Nitroguanosine 3′,5′-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION

Neurofibrillar tangles caused by intracellular hyperphosphorylated tau inclusion and extracellular amyloid β peptide deposition are hallmarks of Alzheimer's disease. Tau contains one or two cysteine residues in three or four repeats of the microtubule binding region following alternative splici...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yoshitake, Jun, Soeda, Yoshiyuki, Ida, Tomoaki, Sumioka, Akio, Yoshikawa, Misato, Matsushita, Kenji, Akaike, Takaaki, Takashima, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077206/
https://ncbi.nlm.nih.gov/pubmed/27601475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734350
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