A Novel Processive Mechanism for DNA Synthesis Revealed by Structure, Modeling and Mutagenesis of the Accessory Subunit of Human Mitochondrial DNA Polymerase

Mitochondrial DNA polymerase (pol γ) is the sole DNA polymerase responsible for replication and repair of animal mitochondrial DNA. Here, we address the molecular mechanism by which the human holoenzyme achieves high processivity in nucleotide polymerization. We have determined the crystal structure...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Mol Biol
Egile Nagusiak: Fan, Li, Kim, Sangbumn, Farr, Carol L., Schaefer, Kevin T., Randolph, Kathleen M., Tainer, John A., Kaguni, Laurie S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2006
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703138/
https://ncbi.nlm.nih.gov/pubmed/16574152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.02.073
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