A Novel Processive Mechanism for DNA Synthesis Revealed by Structure, Modeling and Mutagenesis of the Accessory Subunit of Human Mitochondrial DNA Polymerase

Mitochondrial DNA polymerase (pol γ) is the sole DNA polymerase responsible for replication and repair of animal mitochondrial DNA. Here, we address the molecular mechanism by which the human holoenzyme achieves high processivity in nucleotide polymerization. We have determined the crystal structure...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Fan, Li, Kim, Sangbumn, Farr, Carol L., Schaefer, Kevin T., Randolph, Kathleen M., Tainer, John A., Kaguni, Laurie S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703138/
https://ncbi.nlm.nih.gov/pubmed/16574152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.02.073
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