The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells

The accessory subunit of mitochondrial DNA polymerase γ, POLGβ, functions as a processivity factor in vitro. Here we show POLGβ has additional roles in mitochondrial DNA metabolism. Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids, which often contain multiple copies of the mit...

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Main Authors: Di Re, M., Sembongi, H., He, J., Reyes, A., Yasukawa, T., Martinsson, P., Bailey, L. J., Goffart, S., Boyd-Kirkup, J. D., Wong, T. S., Fersht, A. R., Spelbrink, J. N., Holt, I. J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761280/
https://ncbi.nlm.nih.gov/pubmed/19625489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp614
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