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Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers
In vitro selection was used to obtain L-RNA aptamers that bind the distal stem-loop of various precursor microRNAs (pre-miRs). These L-aptamers, termed “aptamiRs”, bind their corresponding pre-miR target through highly specific tertiary interactions rather than Watson–Crick pairing. Formation of a p...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703082/ https://ncbi.nlm.nih.gov/pubmed/26652064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b06696 |
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