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In vitro selection of l-DNA aptamers that bind a structured d-RNA molecule

The development of structure-specific RNA binding reagents remains a central challenge in RNA biochemistry and drug discovery. Previously, we showed in vitro selection techniques could be used to evolve l-RNA aptamers that bind tightly to structured d-RNAs. However, whether similar RNA-binding prope...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Dey, Sougata, Sczepanski, Jonathan T
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038948/
https://ncbi.nlm.nih.gov/pubmed/31950158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1236
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