A DNA aptamer for binding and inhibition of DNA methyltransferase 1

DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small molecular compounds and DNMTs that suffers from...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Wang, Linlin, Lee, Ju Yong, Gao, Linfeng, Yin, Jiekai, Duan, Yaokai, Jimenez, Luis A, Adkins, Gary Brent, Ren, Wendan, Li, Linhui, Fang, Jian, Wang, Yinsheng, Song, Jikui, Zhong, Wenwan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145629/
https://ncbi.nlm.nih.gov/pubmed/31733056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1083
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