A DNA aptamer for binding and inhibition of DNA methyltransferase 1

DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small molecular compounds and DNMTs that suffers from...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wang, Linlin, Lee, Ju Yong, Gao, Linfeng, Yin, Jiekai, Duan, Yaokai, Jimenez, Luis A, Adkins, Gary Brent, Ren, Wendan, Li, Linhui, Fang, Jian, Wang, Yinsheng, Song, Jikui, Zhong, Wenwan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145629/
https://ncbi.nlm.nih.gov/pubmed/31733056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1083
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