Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation

Influenza virus RNA (vRNA) promoter panhandle structures are believed to be sensed by retinoic acid-inducible gene I (RIG-I). The occurrence of mismatches in this double-stranded RNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoter...

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Vydáno v:J Virol
Hlavní autoři: Anchisi, Stéphanie, Guerra, Jessica, Mottet-Osman, Geneviève, Garcin, Dominique
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702558/
https://ncbi.nlm.nih.gov/pubmed/26446607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01671-15
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