Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction

The molecular pharmacology of the G protein–coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P(3) antagonist, SPM-354, with in vivo activity, has been used, together with S1P(3)-knockin and S1P(3)-kno...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Pharmacol
Prif Awduron: Sanna, M. Germana, Vincent, Kevin P., Repetto, Emanuela, Nguyen, Nhan, Brown, Steven J., Abgaryan, Lusine, Riley, Sean W., Leaf, Nora B., Cahalan, Stuart M., Kiosses, William B., Kohno, Yasushi, Brown, Joan Heller, McCulloch, Andrew D., Rosen, Hugh, Gonzalez-Cabrera, Pedro J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2016
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702096/
https://ncbi.nlm.nih.gov/pubmed/26494861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.100222
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