Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

In Huntington's disease (HD), mutant Huntingtin (mHtt) protein causes striatal neuron dysfunction, synaptic loss, and eventual neurodegeneration. To understand the mechanisms responsible for synaptic loss in HD, we developed a corticostriatal coculture model that features age-dependent dendriti...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Wu, Jun, Ryskamp, Daniel A., Liang, Xia, Egorova, Polina, Zakharova, Olga, Hung, Gene, Bezprozvanny, Ilya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701955/
https://ncbi.nlm.nih.gov/pubmed/26740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1038-15.2016
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